It's 1888, and Rene Sakin, having tragically lost both parents, is expelled from a prestigious medical college for laudanum abuse. Facing ridicule from New York society and determined to move medicine into the 20th century, she heads west to a Tennessee mining town to seek out a mysterious healer--Charles Noble. After Charles restores a blind woman’s sight and saves a child from an incurable disease, Rene risks everything to learn Noble’s secret. Following a night of passion, Noble enlists Rene to help save lives on an Indian reservation while he eradicates typhus in a utopian town. United again, Charles and Rene race across the country to San Francisco, evading evil forces eager to steal Charles' closely guarded healing secret.